ABSTRACT
Se realiazó un estudio descriptivo, retrospectivo y observacional mediante la revisión de 35 historias médicas de pacientes hospitalizados con Neumonía Atípica entre enero de 1999 y mayo de 2006. El grupo etáreo más afectado fue el de 15 a 39 años de edad, que representa el 54.2 por ciento. Los síntomas más frecuentes fueron de origen respiratorio, como son tos (32.5 por ciento) y disnea (26.25 por ciento). El 22.8 por ciento resultó positivo para Mycoplasma y el 20 por ciento para Chlamydia. Al momento del ingreso, se manejó con amtibioticoterapia basada en Levofloxacina en un 29.7 por ciento. Claritromicina en un 16.2 por ciento. Se observo evolución satisfactoria en el 82.8 por ciento de los casos en estudio.
Subject(s)
Humans , Male , Female , Chlamydophila pneumoniae/pathogenicity , Dyspnea/diagnosis , Doxycycline/administration & dosage , Erythromycin/administration & dosage , Mycoplasma pneumoniae/pathogenicity , Pneumonia/diagnosis , Pneumonia/pathology , Radiography, Thoracic/methods , Roxithromycin/administration & dosage , Cough/diagnosis , Clarithromycin/pharmacology , Doxycycline/pharmacology , Erythromycin/pharmacology , Influenza, Human/complications , Medical Records , Roxithromycin/pharmacologyABSTRACT
The antipseudomonal activity of cefoperazone, cefotaxime, ceftazidime, ceftriaxone and unasyn was determined in presence and absence of subinhibitory concentration of roxithromycin [ROX] using a turbidimetric method over 24-hour period against 2 multiresistant Pseudomonas aeruginosa strains isolated from sputum from patients suffering from respiratory tract infections. ROX enhanced variably the antipseudomonal activity of beta-lactams tested, depending on the beta- lactam, the isolate tested and time of incubation. Culturing the bacterial cells for 24 hours in subinhibitory concentration of ROX resulted in more significant inhibition by the beta-lactam tested. Similar observation was noticed even after short time [3 hours] preincubation with subinhibitory concentration of ROX. The data obtained pointed out to the in vitro beneficial effect of ROX beta- lactam regimen against Ps. aeruginosa, particularly by starting with ROX, followed by beta-lactams
Subject(s)
Roxithromycin/pharmacology , Pseudomonas aeruginosa/drug effects , RoxithromycinABSTRACT
The frequency of Streptococcus pyogenes infections with deep tissue and toxic shock syndrome has increased in the last decade throughout the world. Aim: to compare antimicrobial susceptibility of S. pyogenes strains isolated during 1986 and 1994-95. Eighty two S. pyogenes strains isolated in 1986 and 67 strains isolated in 1994-1995, were studied. MIC 50 and 90 were determined by an agar dilution method for penicillin, ampicillin, cefazolin, cefuroxime, erythromicin. roxithromycin and miocamycin. Eighty eight strains came from skin of soft tissues, 19 from surgical wounds, 18 from invasive infections, 15 from pharyngeal swabs and 9 from other locations. All strains were susceptible to penicillin, ampicillin, cefazolin, cefuroxime, roxithromycin and miocamycin. Ninety nine percent of strains were susceptibel to erythromycin. Strains isolated in 1994-95 had a higher MIC 50 and 90 for erythromycin than those isolated in 1986. The changes in susceptibility to erythromycin of recently isolated strains could be due to the widespread use of macrolides in Chile
Subject(s)
Streptococcus pyogenes/drug effects , In Vitro Techniques , Penicillins/pharmacology , Drug Resistance, Microbial , Microbial Sensitivity Tests , Cefazolin/pharmacology , Miocamycin/pharmacology , Cefuroxime/pharmacology , Erythromycin/pharmacology , Roxithromycin/pharmacology , Ampicillin/pharmacologyABSTRACT
El tratamiento antimicrobiano de las enfermedades por transmisión sexual debe ser combinado ya que coexiste más de un agente microbiano. Los nuevos macrólidos azálicos podrían ser activos frente a la mayoría de los agentes y resolver el problema con un solo antimicrobiano. Se estudiaron 100 cepas de neisseria gonorrhoeae, ciprofloxacino fue la droga más activa (CIM 90= 0,015 mcg/ml). El 20 por ciento de las cepas fueron productoras de betalactamasa. De los macrólidos azalicos azitomicina fue el más activo (CIM 90= 0,25 mcg/ml)